Abstract

Major depressive disorders are leading causes of disability worldwide, yet many people remain undiagnosed, are misdiagnosed, and/or ineffectively treated. Diagnosis relies on the clinical assessment of symptoms, and no molecular diagnostic test is available. Epigenetic events and among them RNA editing modifications have been associated with neuropsychiatric disorders and form the molecular interface between genome and environment. The aim of this study is the identification of a specific RNA editing signature in blood of depressed patients

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