S104 Rising Prevalence of Anxiety and Depression in Chronic Pancreatitis: A Nationwide Analysis

Abstract

Introduction: Chronic pancreatitis (CP) is a complex progressive fibro-inflammatory condition that has been shown to have long-term sequalae including chronic pain and decreased pancreatic function. Previous associations between gastrointestinal diseases such as inflammatory bowel disease and psychiatric disorders have been shown to negatively impact disease severity and overall quality of life. Recent studies have shown that psychiatric conditions, such as anxiety and depression (AD), are commonly associated with CP and significantly affect quality of life, burden of disease, and can worsen disease progression. However, no long-term studies evaluating the association between CP and AD has been performed. Methods: This analysis utilizes the National Inpatient Sample (NIS) database between the years 2010 – 2014. This is the first and most representative analysis that utilizes a national database to identify the association of AD in patients with CP. The primary goal is to provide further information about national trends, overall prevalence of disease and associations between patient and hospital characteristics. Results: A total of 75,744 patients with CP were include in our analysis. Of those, 23,323 (31%) patients had a diagnosis of anxiety or depression. Patients with CP and anxiety/depression were likely to be younger, more likely to be female, white, have Medicare or Medicaid insurance and be from hospitals in the Northeast or Midwest. African Americans, Hispanics and patients in hospitals from the South or West were less likely to have a diagnosis of anxiety/depression. The prevalence of anxiety among C P-related hospitalizations has increased from 7.33% in 2007 to 20.02% in 2014. Depression has increased from 18.49% in 2007 to 23.89% in 2014. A diagnosis of Anxiety and Depression has increased from 23.79% in 2007 to 33.44% in 2014. Increasing age in years was associated with an increased risk of mortality, OR 1.07 95% CI (1.04, 1.09, p< 10-5). AD was not associated with an increased risk of mortality, length of stay or hospitalization charges. Conclusion: CP is a prevalent disease with a significant impact on patients’ quality of life and wellbeing. We found that by 2014, 33% of patients had a comorbid diagnosis of AD. These findings can assist clinicians to improve treatment and management by including a comprehensive approach that addresses psychological and social variables.Figure 1.: National Trends in Anxiety and Depression in Chronic Pancreatitis.