S1-02 SESSION 1: NEUROSURGERY INTRACRANIAL HYPERTENSION AND CORTICAL THICKNESS IN SYNDROMIC CRANIOSYNOSTOSIS

Abstract

Introduction: Intracranial hypertension (ICH) is a frequent indication for surgical intervention in syndromic craniosynostosis. Various clinical risk factors have been described, but potential effects on underlying brain morphology have not been investigated. This study seeks to evaluate the impact of ICH risk factors on cerebral cortex thickness in syndromic craniosynostosis. Methods: Patient records and imaging were reviewed for ICH risk factors and demographic data including papilledema, hydrocephalus, moderate to severe obstructive sleep apnea, cerebellar tonsillar position, occipitofrontal circumference curve deflection, age at the time of scan, and sex in 107 syndromic (Apert, Crouzon, Pfeiffer, Muenke, Saethre-Chotzen) craniosynostosis patients. 171 MRI scans of these patients were then analyzed. Average cortical thickness estimates were obtained via an auto-segmentation/ auto-parcellation image processing software (FreeSurfer) and exported for statistical analysis. A linear mixed effects model accounting for repeated measurements, age, gender, and syndrome influences was developed to determine impact of ICH risk factors on cerebral cortex thickness changes (significance p < .05). Results: Average cortical thickness in this cohort was 2.78 ± 0.17 mm with an average age of 8.88 years (range 1.15 – 34.03) at the time of scan. Cortical thickness did not vary significantly by sex (p = 0.534) or syndrome (p = 0.896) as independent predictors. A history of papilledema (p = .036) or hydrocephalus (p = .007) prior to scan date was associated with thinner cortices than those without. Average cortical thickness was also shown to significantly vary with the age of the patient at the time of MRI (p < 0.001), with older patients having thinner cortices. History of moderate to severe obstructive sleep apnea (oAHI > 5) (p = .464), cerebellar tonsil position (p = .682), or history of occipitofrontal circumference curve deflection (p = .375) prior to scan date did not result in significant cortical thickness changes. Conclusions: Our results indicate that a history of hydrocephalus or papilledema results in a thinner cerebral cortex on average in syndromic craniosynostosis patients. This suggests structural consequences from the development of intracranial hypertension and may support early intervention to avoid such effects. Further investigation is needed to evaluate the link between these findings, timing of intervention, and neuropsychological development.