Abstract
The S100 family of EF-hand Ca2+-binding proteins S100A1, S100B and S100A6 are implicated in the pathophysiology of myocardial ischemia-reperfusion (I/R). S100A6 over-expression results in decreased cardiomyocyte apoptosis in vitro. Previously, we showed that after I/R, S100A6 gene expression progressively increases within infarct and peri-infarct regions of the left ventricular (LV) myocardium, well after early apoptosis, LV dilatation and systolic dysfunction. We hypothesized that S100A6 overexpression by ultrasound-targeted microbubble destruction (UTMD) would ameliorate I/R injury.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
