S0693 Differences in Clinical Characteristics and Patient-Reported Outcomes of Recently Hospitalized vs Non-Hospitalized Ulcerative Colitis Patients: Real World Data From Corrona Inflammatory Bowel Disease Registry

Abstract

INTRODUCTION: Ulcerative colitis (UC) is a chronic inflammatory disorder of the gut with extensive disease burden including hospitalization. This study aimed to characterize differences between recently hospitalized and non-hospitalized UC patients. METHODS: We included patients ≥18 years with a physician diagnosis of UC in the Corrona Inflammatory Bowel Disease (IBD) Registry between 2017 and 2020, excluding those with indeterminate colitis (n = 30), missing data (n = 50), or diagnosis changed after enrollment (n = 21). Patients were grouped by UC-related hospitalization in the 12 months prior to enrollment (Y/N), and descriptive statistics and standardized differences (sdiff) (effect sizes) were calculated for characteristics at enrollment, with ≥0.10 indicating potentially meaningful differences. RESULTS: Of 839 patients with UC, n = 133 (15.9%) were hospitalized in the 12 months prior to enrollment (Table 1). 77.8% of the hospitalized and 53.8% of non-hospitalized patients who reported their work status as disabled (n = 35) reported their disability as due to UC (sdiff = 0.521). Hospitalized patients were more likely than non-hospitalized patients to be biologic- (62.4% vs 49.1%; sdiff = 0.271) and corticosteroid (CS)-experienced (70.7% vs 55.0%; sdiff = 0.328). Hospitalized patients had higher current biologic use (sdiff = 0.241), current CS use (25.6% vs 14.4%; sdiff = 0.281), and CS use within the past 3 months (42.9% vs 17.0%; sdiff = 0.589). Hospitalized patients had higher partial Mayo Clinic Scores (3.0 vs 1.9; sdiff = 0.504). Duration of current UC therapy was shorter among the hospitalized group (1.1 vs 2.5 years; sdiff = 0.389) (Table 2). Mean Patient-Reported Outcome Measurement Information System (PROMIS) scores for fatigue, sleep disturbance, pain interference, depression, and anxiety (in prior 7 days) were higher in the hospitalized vs non-hospitalized group (sdiff ≥0.32) (Table 3). Hospitalized patients had greater impairment (higher % is worse) on Worker Productivity and Activity Impairment (WPAI, past 7 days); absenteeism (20.1% vs 3.7%; sdiff = 0.622); presenteeism (36.4% vs 14.5%; sdiff = 0.745); work productivity loss (41.4% vs 16.1%; sdiff = 0.800), and activity impairment (36.1% vs 18.7%; sdiff = 0.585). CONCLUSION: Our study demonstrates that UC patients hospitalized in the 12 months prior had worse PROMIS and WPAI measures at enrollment, and higher biologic and CS use, with shorter time on current therapy compared with non-hospitalized patients.Table 1Table 2Table 3