S041 Identification of the Mechanism of 11q13 Amplification Leads to Detection of DNA Repair Defects in HNSCC Cell Lines

Abstract

allele can induce progression to SCC. Conclusions: These data support a gain-of-function role for p53R172H in oral SCC development and suggest that mutations in p53 not only contribute to late stages of tumor progression but also can cooperate with other genetic alterations in tumor initiation. We are currently analyzing expression profiles of p53R172H squamous cell papilloma in order to identify molecular mechanisms involved in mutant p53-mediated oral cancer progression.