Abstract
Bone matrix production activity of osteoblasts is influenced by the surrounding mechanical environment. However, it has not been clearly understood that how do mechanical stimulus affects osteoblasts collagen production. In this study, we applied cyclic stretch strain to osteoblasts as the mechanical stimulus and evaluated an amount of collagen production by using SHG microscopy. The SHG microscopy methods can observe the collagen at living cell in situ, whereas the conventional staining methods require permeabilization and fixation. As a result, we found that the amount of collagen produced by osteoblasts was increased by the cycle stretch strain application.
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