S&T-08 OBSTRUCTIVE SLEEP APNEA INCREASES THE RISK OF URINARY INCONTINENCE

Abstract

You have accessJournal of UrologyScience & Technology Posters1 Apr 2016S&T-08 OBSTRUCTIVE SLEEP APNEA INCREASES THE RISK OF URINARY INCONTINENCE Shih-Yen Lu, Yu-Hwa Fang, Hsiao-Jen Chung, Eric Yi-Hsiu Huang, Chih-chieh Lin, Alex T.L. Lin, and Kuang-Kuo Chen Shih-Yen LuShih-Yen Lu More articles by this author , Yu-Hwa FangYu-Hwa Fang More articles by this author , Hsiao-Jen ChungHsiao-Jen Chung More articles by this author , Eric Yi-Hsiu HuangEric Yi-Hsiu Huang More articles by this author , Chih-chieh LinChih-chieh Lin More articles by this author , Alex T.L. LinAlex T.L. Lin More articles by this author , and Kuang-Kuo ChenKuang-Kuo Chen More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2016.02.2837AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES A relationship between obstructive sleep apnea (OSA) and urinary incontinence (UI) has been described in the literature. Nevertheless, the exact nature of the association between OSA and UI remains unknown. It is interesting and also important to know whether there is a causal relationship between OSA and UI. METHODS We used data sourced from Longitudinal Health Insurance Database, which consists of one million randomly selected subjects from the National Health Insurance Research Database of Taiwan. Health Insurance System of Taiwan covers approximately 23 million people (98% of population). We identified 1499 incident patients, including 1210 men and 289 women, aged 18 years or older who were diagnosed with OSA (ICD-9-CM codes 780.51, 780.53, 780.57 or 327.23) after receiving polysomnography between January 1997 and December 2009. A cohort of 7495 (5 for each subject with OSA) age and gender matched subjects without the diagnosis of OSA were enrolled as the control group. The study endpoint is developing UI (ICD-9-CM codes 625.6, 788.3) or the last visit before December 2009. Cox shared frailty regression model was used to examine the risk of subsequent UI between cases and control. RESULTS The mean follow-up period was 5.61±2.45 years. Of the sampled patients, the incidences of UI for subjects with OSA were significantly higher than those without OSA (3.6% vs 1.85%, p < 0.001). The incidences of UI in female and male patients with OSA were 9% and 2.31% respectively. Furthermore, the log-rank test revealed that female subjects with OSA had significantly lower 5-year UI-free survival rates than male patients with OSA (p < 0.001). After adjusted for hypertension, diabetes mellitus, hyperlipidemia, heart disease, and ischemic strokes, the Cox shared frailty regression model revealed that the hazard ratio (HR) for UI among subjects with OSA was 1.91 (95% CI 1.39–2.61, P < 0.001). Further analysis of the HR for UI stratified by gender showed the adjusted HR for UI was 2.66 (95% CI 1.66–4.29, P < 0.001) among female patients with OSA compared to the comparison cohort. Nevertheless, the HR for UI in male patients with OSA was 1.53 (95% CI 1.00–2.35, p=0.051) with borderline significance compared to matched comparison subjects. CONCLUSIONS OSA appears to be associated with an increasing occurrence of UI. Moreover, female patients with OSA experience a higher incidence and earlier onset of UI than male patients with OSA. This relationship may have clinical implications for the treatment of affected patients. © 2016FiguresReferencesRelatedDetails Volume 195Issue 4SApril 2016Page: e311 Advertisement Copyright & Permissions© 2016MetricsAuthor Information Shih-Yen Lu More articles by this author Yu-Hwa Fang More articles by this author Hsiao-Jen Chung More articles by this author Eric Yi-Hsiu Huang More articles by this author Chih-chieh Lin More articles by this author Alex T.L. Lin More articles by this author Kuang-Kuo Chen More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...