Abstract
S-Methyl N, N-diethylthiolcarbamate sulfone (DETC-Me sulfone) was investigated for its rat liver mitochondrial low K m aldehyde dehydrogenase (ALDH 2) inhibitory properties. DETC-Me sulfone inhibited ALDH 2 in vitro ( ic 50 = 3.8 μ M ) and in vivo ( id 50 = 170 μ mol/kg; 31 mg/kg ). Maximum inhibition (60%) of ALDH 2 was observed 8 hr after DETC-Me sulfone administration. In addition, incubation of S-methyl N, N-diethylthiolcarbamate (DETC-Me) or S-methyl N, N-diethylthiolcarbamate sulfoxide (DETC-Me sulfoxide) with rat liver microsomes and an NADPH-generating system failed to produce DETC-Me sulfone. Furthermore, DETC-Me sulfone could not be detected in plasma from rats treated with either DETC-Me sulfoxide or DETC-Me sulfone. In conclusion, DETC-Me sulfone inhibited ALDH 2 in vitro and in vivo. However, there was no evidence suggesting that DETC-Me sulfoxide was metabolized to DETC-Me sulfone.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
