Abstract
To thrive within immunocompetent human hosts, pathogenic microorganisms adapt to and resist both innate and adaptive immune responses. For example, the gram-positive bacterium Staphylococcus aureus is highly efficient at infecting humans and evading host immunity. Adding to this health burden is the emergence of multidrug-resistant strains, particularly methicillin-resistant S. aureus (MRSA), that can cause significant hospital-associated infections (HA-MRSA) among immunocompromised patients. In addition, highly virulent community-associated MRSA strains (CA-MRSA) emerged during the past decade, causing disease in otherwise healthy individuals. Thus, new therapeutic agents and antimicrobials are needed.
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