Abstract
S-allylcysteine (SAC) is an aged garlic derived water soluble organosulfur compound and has been suggested to have anticarcinogenic activity against diverse types of cancer cells. This review summa-rizes the cellular signaling pathways and molecular mechanisms whereby SAC exerts its effects on cel-lular proliferation, apoptosis, cell cycle progression and metastasis based on the results from both in vitro and in vivo studies. SAC activates proapoptotic proteins including Bax and caspase-3, but sup-presses antiapoptotic Bcl-2 family proteins to bring about cancer cell death through mitochon-dria-mediated intrinsic pathway. SAC also inhibits cellular proliferation by inducing cell cycle arrest in which SAC reduces expression and activation of NF-
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