S 33 NMR cryogenic probe for taurine detection

Abstract

With the goal of a (33)S nuclear magnetic resonance (NMR) probe applicable to in vivo NMR on taurine-biological samples, we have developed the (33)S NMR cryogenic probe, which is applicable to taurine solutions. The NMR sensitivity gain relative to a conventional broadband probe is as large as 3.5. This work suggests that improvements in the preamplifier could allow NMR measurements on 100 microM taurine solutions, which is the level of sensitivity necessary for biological samples.