Abstract
The presence of S-100 protein positive dendritic cells (S-100(+)DC) in primary hepatocellular carcinoma (HCC) were immunohistochemically investigated in relation to clinicopathological factors. The patients who showed a marked infiltration of S-100(+)DC survived longer especially in the group of non-curative resection (P<0.05). In addition, the density numbers of S-100(+)DC related well with the rate of growth of each tumor nodule calculated by ultrasonography (r=0.575, P<0.01). These results indicate that, S-100(+) DC, acting as antigen presenting cells, may play an important role in the host's immune reaction against HCC and are a useful marker for tumor growth and prognosis in HCC.
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