Abstract
• In a recent study Lobos et al., 2021 [6] show that RyRs and specifically RyR2, the predominant form of this receptor in rat hippocampal neurons, not only amplify calcium levels but strongly contribute to a generation of a nuclear calcium signal. The authors show that an inhibition of RyR-mediated calcium release using ryanodine (Rya) or by depleting RyR2 expression using RNAi blunted nuclear calcium levels in cultured rat neurons by approximately 50-75%.
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