Abstract
Spontaneous contraction of mouse heart muscle in tissue culture is stopped by ryanodine at 1–2 mg/ml. These concentrations also block mitosis. In the dividing Echinarachnius egg, anaphase movement of chromosomes is retarded and incomplete in ryanodine at 6–8 mg/ml, although some of the eggs complete 2 or 3 cleavages. Increasing the length of exposure prior to cleavage does not alter the character of response and only slightly increases the severity. These phenomena are consistent with an inhibition of traction fiber contraction by ryanodine, but are insufficient to demonstrate the existence of such a contractile phenomenon.
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