RWD87 Association Between Functional Endpoints and Quality-of-Life Outcomes in Huntington's Disease Gene Carriers: Results From a Real-World Data Analysis of the Enroll-HD Global Registry

Abstract

Huntington’s Disease (HD) is an autosomal dominant neurodegenerative disorder that leads to progressive loss of functional capacity. This retrospective, registry-based study assessed the associations between HD functional endpoints measured by the Unified HD Rating Scale (UHDRS) Total Functional Score (TFC) and other scales (Total Motor Score [TMS] , Verbal Fluency Test [VFT], Problem Behavior Assessment [PBA]-Apathy), and quality-of-life outcomes (QoL) measured by Short-Form Survey 12 (SF-12) and other QoL scales (Euro-QoL-5D [EQ-5D], Work Productivity and Activity Impairment-Overall Work Impairment due to HD [WPAI-OWIHD]) in HD gene carriers.