Abstract
In February 2000, the NIH National Library of Medicine developed ClinicalTrials.gov, a now widely used database of publicly and privately funded clinical studies around the world. Real-world evidence (RWE) studies are types of clinical studies that have burgeoned into a widely used tool to inform healthcare decision making. Study registration is important for transparency, replicability, and RWE synthesis purposes. The exact frequency and trends in RWE registrations in the ClinicalTrials.gov database bears further examination.
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