Abstract
Objective: Diabetes mellitus (DM) is associated with long-term damage, dysfunction, of various organs. Study aims to assessrole of rutin on experimentally induced diabetes.
 Methods: 50 adult male albino rats divided into 5 groups. Group I (control group, rats were orally administered with 1 ml saline daily). Group II (DMSO group, rats were orally administered with 0.2 % DMSO for 60 d orally). Group III (positive control, animals were injected intraperitoneally with 60 mg/kg b. wtstreptozotocin followed by intraperitoneal injection with 120 mg/kg b. wt of Nicotinamide after 15 min). Group IV (therapeutic group, diabetic rats treated with 100 mg/kg b. wt of rutin for 60 d orally). Group V (standard group, diabetic animals treated with 100 mg/kg b. wt of metformin for 60 d orally). At the end of the experimental period blood serum and plasma, liver, kidney and pancreatic tissues were collected.
 Results: Diabetic rats showed a significant increase in plasma glucose, serum urea, creatinine, cholesterol and triglyceride. Also, induced oxidative stress as pointed out an increase in MDA level, decrease in GSH level, GST and CAT activities in compared to control group. Also, showed an increase in plasma and tissues levels of betatrophin. Oral administration of rutin cause decrease in elevated biochemical and oxidative stress parameters. Also, decrease betatrophin level when compared with diabetic rats. Our results were confirmed by histopathological examination of different tissues.
 Conclusion: This study suggests thatrutinexihibitsantihyperglycemic and antioxidant activity in streptozotocin-induced diabetic rats.
Highlights
Diabetes mellitus (DM) is one of the most important health problems in all world
DM is a metabolic disease characterized by chronic high blood glucose with an imbalance in metabolism of carbohydrates, proteins and fat caused by impair in insulin secretion, insulin action, or both
There was significant decrease (p
Summary
Diabetes mellitus (DM) is one of the most important health problems in all world It is the seventh cause of death all over the world [1]. DM is a metabolic disease characterized by chronic high blood glucose with an imbalance in metabolism of carbohydrates, proteins and fat caused by impair in insulin secretion, insulin action, or both. It is symptoms were thirst, urination, impair vision, and decrease in weight. Through the STZ metabolism, highly reactive carbonium ions (CH+5) are produced, that induce alkylation of DNA bases and STZ may damage the membrane of β cell and break the DNA strand which causes activation of poly (ADP-ribose) synthetase and NAD decrease, which leads to cell death [3]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Current Pharmaceutical Research
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
