Abstract
Diabetic cardiomyopathy (DCM), an independent coronary heart disease that develops in diabetic individuals, is characterized by changes in the myocardial structure and function. The aim of the present study was to investigate the protective effect of rutin on DCM in a streptozotocin-induced diabetic rat model. Rutin was orally administrated at a dose of 8 mg/kg body weight. Metabolic profiles, myocardial enzymes and oxidative stress were examined by biochemical tests. The expression levels of cellular proteins associated with apoptosis were measured by western blot analysis, while the levels of inflammatory factors were assessed by immunohistochemical analyses. Rats with DCM exhibited an abnormal metabolic profile, aberrant myocardial enzymes, elevation of oxidative stress markers, increased levels of inflammatory factors and enhanced apoptotic cell death. Notably, rutin was shown to protect and improve myocardial dysfunction, oxidative stress, apoptosis and inflammation in the hearts of the diabetic rats. In conclusion, these results indicated that rutin may have great therapeutic potential in the treatment of DCM, and possibly other cardiovascular disorders, by preventing oxidative stress, inflammation and cell death. However, further detailed studies are required to reveal the exact mechanisms underlying the protective effect of rutin.
Highlights
Diabetes mellitus (DM) is accompanied by a number of complications due to the abnormal control of glycometabolism and lipid metabolism
The metabolic abnormalities observed in the DM group, including the markedly higher concentrations of plasma and serum glucose (P
The concentration levels of plasma and serum glucose in the DM + rutin group were not reduced to the same extent as that observed in the control group, the levels were significantly decreased compared with the level in the DM group (P
Summary
Diabetes mellitus (DM) is accompanied by a number of complications due to the abnormal control of glycometabolism and lipid metabolism. Diabetic cardiomyopathy (DCM), Key words: diabetic cardiomyopathy, rutin, diabetic rats, streptozocin, antioxidants a condition observed in diabetic individuals, is characterized by changes to the myocardial structure and function, independent of coronary artery disease and systemic hypertension [1,2]. An increase in the levels of blood lipoproteins and free fatty acids facilitates the development of cardiovascular diseases, including hyperlipidemia and coronary artery disease, which can lead to further complications, such as retinopathy, nephropathy, neurosis, nephrotoxicity and hyperglycemia‐induced coma [3]. Diabetic complications are generally considered to be the result of oxidative stress [4], the excessive production of reactive oxygen species (ROS) and the aberration of the antioxidant system [5]. Diabetic complications are interrelated with the inflammatory response, and have been shown to be accelerated under a hyperglycemic state for the production of acute response factors in fat cells [6,7,8]
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