Abstract
A phenanthrene derivative with a pendant methanol amidogen TFCPIP and its two ruthenium(II) complexes [Ru(phen)2(TFCPIP)](ClO4)2 (1) and [Ru(dmp)2(TFCPIP)](ClO4)2 (2) (phen = 1,10-phenanthroline, dmp = 2,9-dimethyl-1,10-phenanthroline, TFCPIP = 2-(2,3,5,6-tetrafluoro-4-aminoethanolphenyl)[4,5-f]-imidazo[1,10]phenanthroline) were synthesized, and the anticancer properties of the two complexes were examined. Both the complexes displayed certain anticancer activities against the selected SGC-7901, BEL-7402, HeLa, A549, MG-63, HepG2, PC-12 and SiHa cancer cells, with the highest cytotoxic activities against SGC-7901. The cell biology experiments for exploring toxicity mechanism with fluorescence imaging technique and flow cytometry demonstrated that the complexes can trigger apoptosis of SGC-7901 cells with an increase in ROS level, a decrease in mitochondrial membrane potential, and effectively inhibit cell invasion and cell growth at G2/M phase, implicating that the complexes induce cellular apoptosis through a ROS-mediated mitochondrial dysfunction pathway.
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