Abstract

AbstractAn efficient synthetic strategy employing pyridyl C−X activation, for the generation of N‐alkyl‐2‐pyridones from N‐alkyl‐2‐halopyridinium salts is described. As pyridones are dearomatised synthetic derivatives of pyridines, a versatile scope exist for pyridyl C−H functionalisation. The present strategy exemplifies a straight forward in‐situ generation of Ru(VIII), leading catalytic dearomative synthesis of pyridones. The N‐alkyl‐2‐pyridones are further reduced to N‐alkyl‐2‐piperidones and a plausible mechanism is also drawn, which is supported by some controlled reactions.

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