Abstract
Ruthenium complexes are among the most interesting coordination complexes and they have attracted great attention over the past decades due to their appealing biological, catalytic, electronic and optical properties. Ruthenium complexes have found a unique niche in bioanalysis, as demonstrated by the substantial progress made in the field. In this review, the applications of ruthenium complexes coordinated with polypyridine ligands (and analogues) in bioanalysis are discussed. Three main detection methods based on electrochemistry, electrochemiluminescence, and photoluminscence are covered. The important targets, including DNA and other biologically important targets, are detected by specific biorecognition with the corresponding oligonucleotides as the biorecognition elements (i.e., DNA is probed by its complementary strand and other targets are detected by functional nucleic acids, respectively). Selected examples are provided and thoroughly discussed to highlight the substantial progress made so far. Finally, a brief summary with perspectives is included.
Highlights
Since Alfred Werner’s pioneering work more than one hundred years ago, substantial progress has been made in the field of coordination chemistry
Ruthenium complexes coordinated with polypyridine ligands have received considerable attention due to their unique biological, catalytic, electronic and optical properties, and their emerging applications in bioanalysis, bioimaging, solar cells, and organic light-emitting diodes [26,27,28,29,30,31,32]
DNA detection based on Watson-Crick base-pairing recognition and the detection of other important targets with functional nucleic acids as biorecognition elements will be highlighted
Summary
Since Alfred Werner’s pioneering work more than one hundred years ago, substantial progress has been made in the field of coordination chemistry. Ruthenium complexes coordinated with polypyridine ligands (and analogues) have received considerable attention due to their unique biological, catalytic, electronic and optical properties, and their emerging applications in bioanalysis, bioimaging, solar cells, and organic light-emitting diodes [26,27,28,29,30,31,32]. DNA detection based on Watson-Crick base-pairing recognition and the detection of other important targets with functional nucleic acids (such as aptamer and DNAzymes) as biorecognition elements will be highlighted.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.