Ruthenium(II)‐Catalyzed Selective C(sp2)−H Acyloxylation of 2‐Aroyl‐Pyridine Derivatives with Sodium Carboxylate

Abstract

AbstractA ruthenium‐catalyzed C(sp2)−H acyloxylation of 2‐aroyl pyridine derivatives with simple sodium carboxylate utilizing transformable directing groups is described. This protocol features broad functional group tolerance and chemo‐ and regio‐selectivity, providing the acyloxylation products in 45%‐84%yield. Furthermore, the synthetic utility of this protocol was demonstrated by the late‐stage functionalization of pharmaceutical compounds. Notably, the acyloxylation products could be further transformed into a variety of useful heterocycles under mild conditions.