Russian

Abstract

Injuries are among the most frequent causes of hospitalization in emergency surgery clinics. Currently, the incidence of injuries in the population is 1:1000 per year, and the mortality rate ranges from 1.5 to 5.9 %. For treatment of wounds uses a wide range of the local application on the basis of natural and artificial ingredients. In recent decades, a number of studies devoted to the use of chitosan for the treatment of wounds of various etiologies. But data regarding the activities of chitosan-based materials on the treatment of wounds of mechanical etiology in age aspect are pure. The aim of our research - the study of the parameters of wound surface in animals of different ages during the application of chitosan membranes. The experiment was conducted on 180 laboratory animals - young, mature and old age, which simulated mechanical trauma in interscapullar area. Experimental series were carried out daily applique innovative chitosan membranes. To control the process of skin regeneration was used method of planimetric study. Age features of mechanical etiology wound healing are to reduce the speed of cleaning the surface of the necrotic mass and slowing the formation of the epithelial layer. Application of chitosan membranes for the treatment of mechanical trauma leads to an acceleration of cleansing the wound from necrotic tissue, increased the speed of transformation of granulation in the connective tissue and as a result - complete epithelialization of the defect without scar formation.