Russian

Abstract

Bone injury is a powerful factor that leads to remodeling of the entire organ. When this change rate adjustment processes dependent on many factors including the age. There is strong evidence of changes in the skeleton of a young, mature and old age in terms of long bone injuries. But it is poorly understood changes in other age periods. The aim of our work was to study bone growth and bone microhardness after defect modeling of the tibia in animals of different age periods. Under sterile operating was applied defect of medial surface of the body with the middle third of the tibia. After 10, 15 and 24 days after defect application were study osteometric parameters and bone microhardness. Tibia injury leads to disruption of the longitudinal growth processes in animals of young and adult ages, which is probably due to dysfunction of the epiphyseal growth plate. Also seen the development of periosteal reaction, which is accompanied by changes in the transverse dimensions of the bone. In animals of presenile and senile ages were not observe changes of bone growth parameters. Microhardness bone tends to lower in animals of all ages. While in rats of young and adult ages observed normalization of this parameter to the 24 day, in animals of presenile and senile age there is a decrease of microhardness, which is a risk factor for recurrent fractures.