Abstract
Warfarin might be the most commonly used oral anticoagulant. 1 Bernaitis N Ching CK Badrick T Anoopkumar-Dukie S Identifying Warfarin Control With Stroke and Bleed Risk Scores. Heart Lung Circ. 2018; 27: 756-759 Summary Full Text Full Text PDF PubMed Scopus (4) Google Scholar It was first used as a rodenticide in the 1940s, but found wide acceptance for medical use after the discovery of vitamin K as an antagonist of its action. 2 Wardrop D Keeling D The story of the discovery of heparin and warfarin. Br J Haematol. 2008; 141: 757-763 Crossref PubMed Scopus (248) Google Scholar The characterisation of the anticoagulant properties of warfarin resulted from years of research by Karl Link, at the University of Wisconsin in Madison, USA, and his students Harold Campbell and Mark Stahmann. Their experiments first led to the isolation of dicoumarol 2 Wardrop D Keeling D The story of the discovery of heparin and warfarin. Br J Haematol. 2008; 141: 757-763 Crossref PubMed Scopus (248) Google Scholar and then to the development of warfarin, a more potent anticoagulant than dicoumarol. 2 Wardrop D Keeling D The story of the discovery of heparin and warfarin. Br J Haematol. 2008; 141: 757-763 Crossref PubMed Scopus (248) Google Scholar
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