Abstract
Rupestrisine A (1), an unprecedented heteroyohimbine-kopsinine type dimeric indole alkaloid, and rupestrisine B (2), the first example of yohimbine-kopsinine type bisindole alkaloid, were isolated from Alstonia rupestris. Their structures were elucidated based on 1D and 2D-NMR, MS, ECD, FTIR and UV spectroscopic data. Compound 1 showed moderate activity of inhibiting NO production of RAW264.7 cells induced by lipopolysaccharide with an IC50 value of 17.5 ± 1.6 μM.
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