Abstract
RUNX3 methylation and anti-tumor immunity.
Highlights
During differentiation, cell lineages acquire stable and heritable gene expression programs associated with characteristic epigenetic marks, including DNA methylation
It had not escaped our attention that RUNX3, a key regulator of haematopoiesis, is highly expressed in several immune cell lineages [6]
A key question not addressed in our study is whether RUNX3 P1 methylation, as a surrogate of leukocyte influx, might classify gastric tumors into useful prognostic categories? As a case in point, lymphocyterich Gastric cancer (GC) generally has a better prognosis than GC lacking significant lymphocytic infiltrate [7]
Summary
Cell lineages acquire stable and heritable gene expression programs associated with characteristic epigenetic marks, including DNA methylation. Our analysis utilised whole tissues/ tumors comprised primarily by cancer epithelial cells, and by non-neoplastic cell types including leukocytes. It had not escaped our attention that RUNX3, a key regulator of haematopoiesis, is highly expressed in several immune cell lineages [6].
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