Abstract
Objective: Runt-related transcription factor (RUNX) proteins play an important role during morphogenesis and development of craniofacial structures. However, its role in salivary gland (SG) tissues and tumors needs to be explored. In this study, we evaluated the expression of RUNX1 in a series of SG tumors. Study design: Immunohistochemical RUNX1 expression was evaluated in 20 mucoceles, 30 pleomorphic adenomas, 15 carcinomas ex pleomorphic adenomas, 15 myoepitheliomas, 5 myoepithelial carcinomas, and 30 adenoid cystic carcinomas (ACC). The number of positive nuclei was quantified by a digital computer-assisted method. Results: Nuclear RUNX1 expression was noted mainly in ductal and myoepithelial cells of normal ducts and in mucoceles, only macrophages were positive. Nuclear RUNX1 expression was significantly higher in malignant than in benign SG tumors (P
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