Abstract
RUNX1 as a recombinase cofactor.
Highlights
Intrinsic recombination signal sequences (RSS) features had been reported to be directly involved in the control of V(D)J recombination beyond chromatin accessibility [1]
In a recent report [5], we showed that human TCRδ gene rearrangements are strictly controlled by a Beyond 12/23 restriction involving the RUNX1 transcription factor, which behaves as a co-factor for the V(D)J recombinase: RUNX1 binds to Dδ2-23RSS, interacts with RAG1 and enhances RAG1 deposition to Dδ2-23RSS (Figure 1)
RUNX1 imposes the use of two Dδ gene segments in all rearranged TCRδ chains during human TCRδ locus recombination
Summary
Intrinsic RSS features had been reported to be directly involved in the control of V(D)J recombination beyond chromatin accessibility [1]. Given the importance of ordered recombination, extensive research has led to the identification of a critical role of RAG targeting or “RAG loading” to specific RSS by transcription factors [4]. In a recent report [5], we showed that human TCRδ gene rearrangements are strictly controlled by a Beyond 12/23 restriction involving the RUNX1 transcription factor, which behaves as a co-factor for the V(D)J recombinase: RUNX1 binds to Dδ2-23RSS, interacts with RAG1 and enhances RAG1 deposition to Dδ2-23RSS (Figure 1).
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