Abstract
Leaves of Ixora undulata Roxb. were investigated phytochemically for the first time for its alkaloidal content, which resulted in the isolation of a novel unusual thiazepine alkaloid glycoside identified as 7-[(β-D-glucopyranosyl)oxy]-6-hydroxy-2-methoxy-4,5-dihydro-1,3-thiazepine and trivially named as Rubiothiazepine. Its structure was determined on the basis of 1D and 2D NMR (1H-, 13C-NMR, 1H-1H COSY, 1H-13C HETCOR, 1H-13C HMBC, 1H-15N HMBC and DIFNOE), high resolution ESI-CID-MS/MS, UV and IR spectroscopy. The isolated compound showed cytotoxic activity against EL4 (Murine Leukemia) with IC50 >100 μg/mL, and also showed cytotoxic and HIV-1 activity against MT-4 and HIV-1IIIB with CC50 >100 μg/mL and EC50 >100 μg/mL, respectively
Highlights
Ixora undulata Roxb. is native to North Africa, Southern Europe and Asia, and it can be cultivated in moderate climates
I. undulata is an evergreen shrub 6 to 8 ft., it belongs to family Rubiaceae which comprises of 400 genera, from which the genus Ixora consists of 300 species; three of which were cultivated in Egypt; Ixora coccinea, Ixora finlaysoniana and Ixora undulata [1]
The genus Ixora has been used in the Ayurvedic system of medicine for a variety of ailments e.g., leaves in diarrhea, antimicrobial and anti-inflammatory; roots in hiccough, fever, scores, chonic ulcers and skin diseases; flowers in catarrhal bronchitis, dysentery, cytotoxic and antitumor principles
Summary
Rubiothiazepine a Novel Unusual Cytotoxic Alkaloid from Ixora undulata Roxb. D. Mohammed1,2*, Nabaweya A Ibrahim, Ming Chen and Lin Zhai3 1Danish Institute of Agricultural Sciences, Department of Food Science, Research Center Aarslev, Kirstinebjergvej 10, DK-5792 Aarslev, Denmark 2Pharmacognosy Department, National Research Center, Dokki-12311, Cairo, Egypt 3Department of Clinical Microbiology, University Hospital of Copenhagen (Rigshospitalet), Tagensvej 20, DK-2200 Copenhagen N, Denmark
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