Abstract
In order to study the influence of rubidium (Rb) addition on the phase composition, microstructure, mechanical properties and cell response of bioactive glass-ceramics, CaO–SiO 2 –Na 2 O–B 2 O 3 –MgO–ZnO–P 2 O 5 glass system was designed with and without addition of Rb. The results show that hydroxyapatite (HA) and Mg–whitelockite (Ca 18 Mg 2 H 2 (PO 4 ) 14 ) crystalline phases are formed in the glass matrix without Rb. After the addition of Rb, only HA phase is detected. The grain size of the crystals in the glass-ceramics is larger with the addition of Rb than that of samples without Rb. Rb addition can improve the bending strength of glass-ceramics. The cultivation of human bone marrow mesenchymal stem cells (hBMSCs) on Rb-containing glass-ceramics demonstrates enhanced cell adhesion, proliferation and ALP activity. In conclusion, Rb-modified glass-ceramics exhibit good mechanical property, excellent bioactivity and biocompatibility, which have potential for bone regeneration application.
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