Abstract
Rubiadin is identified as a bioactive anthraquinone that exists in some quinone rich plants. The current research was carried out to evaluate the potential anti-inflammatory impact of Rubiadin in acute and chronic inflammation test models in rodents. The anti-inflammatory activity of Rubiadin was examined in cotton pellet-induced granuloma and carrageenan-induced edema as chronic and acute inflammation models in rats. TNF-α level and histopathological changes were assessed using sampled foot tissue of rat in the acute model. Also, the IL-1β level was assessed in the chronic model. One-way ANOVA (post hoc Tukey's) analysis was used for comparing the groups. Rubiadin (0.5 mg/kg, i.p.) induced a significant reduction in TNF α level and the paw edema compared to the control group in carrageenan test. Also, it was observed that the anti-inflammatory activity of Rubiadin (0.5 mg/kg, i.p.) is comparable to mefenamic acid (30 mg/kg, i.p.) as the standard drug. Rubiadin was effective in granuloma induced by cotton pellet concerning the granuloma and transudate formation amount. Rubiadin's anti-inflammatory effects were associated with a significant IL-1β decrease in this model. The results suggest that Rubiadin as a natural compound can possess significant peripheral anti-inflammatory impacts.
Highlights
Rubiadin; with preferred IUPAC name 1, 3-Dihydroxy-2methylanthracene-9,10-dione; as a bioactive anthraquinone from the plants belong to the Rubiaceae family possesses antioxidant, nephroprotective, hepatoprotective, and immunomodulatory impacts (Divakar et al, 2010; Rao et al, 2006)
The present research is the first report that described the anti-inflammatory activity of Rubiadin on chronic and acute inflammation experiment models in rodents
Our results indicate that Rubiadin (0.5 mg/kg) causes an anti-inflammatory impact in carrageenan-induced inflammation
Summary
Romina Chitsaza, Atefeh Zarezadeha, Jinous Asgarpanahb , Parvaneh Najafizadeha,c and Zahra Mousavia* aIslamic Azad University, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Department of Pharmacology and Toxicology, Tehran, Iran b Islamic Azad University, Faculty of Pharmacy and Pharmaceutical Sciences, Tehran Medical Sciences, Department of Pharmacognosy, Tehran, Iran cIran University of Medical Sciences, Department of Pharmacology, Tehran, Iran
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have