Rubella: Frequency of antibody among children and adults and isolation of the virus from fetal tissues, a report from the Collaborative Study of Cerebral Palsy

Abstract

We believe this study supplies data to support a multiple etiology concept of acute glomerulonephritis. Dr. Etteldorf inquired into the antibiotic history since these drugs have been shown to prevent a significant rise in the ASO titer. Only 2 children in each group received antibiotic therapy previous to hospitalization. The 2 children in the low ASO group did not receive penicillin but a tetracycline. Since antibiotics were used in only 2 out of 12 children, we feel that antibiotics could not be responsible for the low ASO titer. Dr. Burke was concerned with chronleity and asked for functional clearances to help differentiate acute from chronic nephritis. We did not do creatinine or inulin clearances but we did follow our patients with sedimentation rate and Addis count determinations. You will remember that most of our children in the low ASO group had recovered within three months, suggesting an acute process ra ther than a chronic process.