Abstract
A straightforward process for hydrodebenzylation of benzyl protected acid and alcohol derivatives to the corresponding acids and alcohols using sodium hypophosphite in the presence of Ru-GCN catalyst is reported. The developed Ru-GCN catalyst is cost effective compared to other noble metal-based catalysts and has been explored to exhibit excellent activity for catalytic hydrodebenzylation reactions under moderate reaction conditions. The non-corrosive sodium hypophosphite has been found as a better hydrogen donor compared to alkali metal formats in presence of Ru-GCN catalyst. The stated catalyst was characterized using several spectrometric and material characterization methods such as PXRD, IR, SEM, TEM, XPS, and TGA. The Ru-GCN catalyst corroborated good reusability and stability for multiple cycles. The catalyst preparation is facile and the developed process is simple and safe as it avoids use of high hydrogen pressure. The developed protocol can also be replicated on industrial scale on account of excellent recyclability and retained activity after multiple cycles and makes the process sustainable. Gram scale reaction was performed to verify the industrial potential of reported catalyst.
Highlights
Protection and de-protection of alcohol and acid groups is an important methodology in the field of fine chemicals and pharmaceutical industries
It is straightforward method to prepare benzyl protecting group and has good stability during various chemical transformation reactions [5]. This methodology has developed into a necessary tool to design a multistep route of organic synthesis in the fine chemicals and pharmaceutical industries as well as in basic or applied research [5–7]
Ru-graphitic carbon nitride (GCN) catalyzed hydrodebenzylation by transfer hydrogen methodology was reported in this paper
Summary
Protection and de-protection of alcohol and acid groups is an important methodology in the field of fine chemicals and pharmaceutical industries. Energy dispersive spectroscopy (EDS) analysis of the Ru‐GCN material further proves the presence of the component the Ru nanoparticles on the GCN surface has been found to be around 1–2 nm and the particles are distributed effectively throughout the support surface (Figure 4c). The elemental mapping of Ru-GCN catalyst shows presence and the distribution of elements such as C, N, O, and Ru in the Ru-GCN material (Figure S2).
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