RTOG 0537 Phase II/III Study Comparing Acupuncture-like Transcutaneous Electrical Nerve Stimulation (ALTENS) versus Pilocarpine in Treating Early Radiation-Induced Xerostomia (RIX): Phase II Results

Abstract

Current treatment for RIX mainly relies on cholinergic agents with moderate side effects. A single institutional phase I/II study suggested ALTENS improves RIX with better xerostomia symptom scores and increased whole saliva production (WSP) with no significant side effects. We are examining ALTENS versus pilocarpine in treating RIX in a multicenter phase II/III randomized prospective study.