Abstract
Respiratory syncytial virus (RSV) is a common cause of upper respiratory tract infections, and in some children causes wheezing and potentially lethal damage to the lower respiratory tract. More-severe infections are accompanied by the release of largely T helper (Th)1-type inflammatory cytokines. It has proved difficult to engineer a vaccine to protect children at risk of serious illness as host–virus interactions are unclear. The RSV genome encodes 11proteins, of which only two induce antibodies capable of neutralizing virus–the F and Gglycoproteins.
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