Abstract
Purpose/Objective: Interstitial tumor oxygen measurements and radiosensitivity assays have established that RSR13 (efaproxiral), a synthetic allosteric modifier of hemoglobin that decreases hemoglobin-oxygen binding affinity, improves radiosensitivity in vivo by reducing the hypoxic fraction in solid tumors. To characterize the micro-regional distribution of RSR13-mediated oxygenation and evaluate its effect upon hypoxia-induced gene expression, a xenograft model was analyzed for the geographic pattern of changes in hypoxia and the resulting impact upon hypoxia-inducible factor 1-alpha (HIF1-α) expression.
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