Abstract
RSR132-[4-[[(3,5-dimethylanilino)carbonyl]methyl]phenoxyl]-2-methylproprionic acid sodium salt; (Figure 1) is a compound that mimics the natural physiological effects of 2,3-diphosphoglycerate by allosterically modifying hemoglobin (Hb) saturation. RSR13 binds to and stabilizes deoxyHb in vitro (1). These actions cause a rightward shift of the oxygen (O2)-Hb dissociation curve and increase tissue O2 delivery in vivo (2). RSR13 maintains pH and preserves high-energy phosphates during myocardial ischemia by improving O2 delivery (3). Thus, allosteric modification of Hb affinity for O2 with drugs that stabilize the deoxyHb may be an important new approach to the treatment of myocardial hypoxemia due to ischemic heart disease. We tested the hypothesis that RSR13 enhances the recovery of contractile function of postischemic, reperfused myocardium generated by repetitive, brief episodes of ischemia and reperfusion in barbiturate-anesthetized, acutely instrumented dogs.KeywordsLeft Anterior DescendMyocardial Blood FlowAllosteric ModifierStun MyocardiumRightward ShiftThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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