Rs744166 polymorphism of the STAT3 gene is associated with risk of gastric cancer in a Chinese population.

Kexin Yuan,Wenjing Tian,Huimin Liu,Lina Huang,Jingjing Liu,Yunhe Jia,Xiaoqun Dong,Xiyun Ren

doi:10.1155/2014/527918

Abstract

The aim of this study was to explore the association between polymorphisms in signal transducer and activator of transcription protein 3 (STAT3) and the risk of gastric cancer. In the present study, a case-control study was conducted in which rs2293152 and rs744166 polymorphisms in STAT3 were analyzed in 209 Chinese patients with gastric cancer and 294 cancer-free controls. The genotypes were determined by polymerase chain reaction restriction fragment length polymorphism method. For the rs744166 polymorphism, the TC genotype (adjusted OR = 0.60, 95% CI = 0.39–0.92, and P = 0.020) and CC genotype (adjusted OR = 0.41, 95% CI = 0.21–0.80, and P = 0.009) were associated with a decreased risk of gastric cancer compared to the TT genotype. However, rs2293152 did not show any difference in gastric cancer risk between patients and controls in the CG/CC genotype compared to the GG genotype. Besides, the SNP effects were additive to the effects of environmental factors without any interaction between them in the susceptibility to gastric cancer. Collectively, rs744166 polymorphism might be significantly associated with a decreased risk of gastric cancer in a Chinese population. Additionally, polymorphisms in STAT3, along with environmental factors, might be associated with the development of gastric cancer.

Highlights

In recent years, gastric cancer (GC) incidence rates have decreased substantially in most parts of the world
Signal transducer and activator of transcription 3 (STAT3), which transmits a wide range of cytokines, was first identified in 1994 as an IL-6-activated acute-phase response factor (APRF) [29]
Several STAT3 single-nucleotide polymorphisms (SNPs) were reported to be significantly associated with cervical cancer, nonsmall cell lung cancer, metastatic renal cell carcinoma, prostate cancer, and hepatocellular cancer

Summary

Introduction

Gastric cancer (GC) incidence rates have decreased substantially in most parts of the world. The JAK/STAT pathway transmits a wide range of regulatory factors that modulate gene transcription, including cytokines, growth factors, and hormones [6]. Aberrant expression and constitutive activation of STAT3 are involved in a broad range of human malignancies, including gastric, breast, prostate, and nonsmall cell lung cancers [9,10,11,12]. Recent studies have identified STAT3 activation as a key event in regulating cell growth, motility, migration, invasion, angiogenesis, and immune response in GC [8, 9, 13,14,15,16,17]. It was reported that Helicobacter pylori (H. pylori) CagA protein activated the STAT3 signaling pathway in gastric

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