Rs6923761 gene variant in glucagon-like peptide 1 receptor: Allelic frequencies and influence on cardiovascular risk factors in a multicenter study of Castilla-Leon

D.A De Luis,M Ballesteros,A Lopez Guzman,E Ruiz,C Muñoz,M.A Penacho,P Iglesias,A Maldonado,V Puigdevall,M Delgado

doi:10.1016/j.clnu.2017.10.013

D.A De Luis, M Ballesteros + Show 8 more

Open Access

https://doi.org/10.1016/j.clnu.2017.10.013

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Abstract

Some GLP-1 receptor studies have identified polymorphisms in the GLP-1 receptor gene that might be related to different cardiovascular risk factors. Our aim was to investigate the allelic distribution of rs6923761 GLP-1 receptor polymorphism in a geographic area of Spain (Community of Castilla y Leon) and to evaluate the influence of this polymorphism on obesity anthropometric parameters and cardiovascular risk factors in the fasted state in obese patients. A sample of 341 obese subjects (body mass index≥30kg/m2) was analyzed. Fasting blood glucose, C-reactive protein (CRP), plasma insulin, insulin resistance (HOMA-IR), and lipid profile were determined. Anthropometric parameters, dietary intake and blood pressure were recorded. One hundred and forty three patients (42.0%) had the genotype GG (wild-type group) and one hundred and ninety eight (58.0%) patients were A carriers: GA (164 patients, 48.1%) or AA (34 patients, 9.9%) (mutant-type group). Valladolid and Segovia health areas had the lowest percentage of wild type genotype and G allelic (than other Health Areas). Burgos Health Area had a higher percentage of wild-type genotype. In wild-type group (GG genotype), BMI (0.9±1.3kg/m2; p<0.05), weight (3.3±1.1kg; p<0.05), fat mass (2.5±1.1kg; p<0.05), waist to hip ratio (0.02±0.005cm; p<0.05), waist circumference (2.8±1.1cm; p<0.05), triglycerides (14.4±3.3mg/dl; p<0.05) insulin (3.1±1.0mg/dl; p<0.05) and HOMA-IR (1.2±0.9mg/dl; p<0.05) were higher than A allele carriers. In non A allele carriers, lower HDL cholesterol levels than A allele carriers (6.4±2.3mg/dl; p<0.05) were found. Data from our study revealed different allelic distribution in this geographic area, with better parameters (Body mass index, weight, fat mass, waist circumference, triglycerides, insulin, HOMA-IR and HDL cholesterol) in A allele carriers than in non A allele carriers.

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