RS 10767664 gene variant in Brain Derived Neurotrophic Factor (BDNF) affect metabolic changes and insulin resistance after a standard hypocaloric diet

Abstract

BackgroundRole of BDNF variants on change in body weight and cardiovascular risk factors after weight loss remains unclear in obese patients. ObjectiveOur aim was to analyze the effects of rs10767664 BDNF gene polymorphism on body weight, cardiovascular risk factors and serum adipokine levels after a standard hypocaloric diet in obese subjects. DesignA Caucasian population of 80 obese patients was analyzed before and after 3months on a standard hypocaloric diet. ResultsFifty patients (62.5%) had the genotype AA and 30 (37.5%) subjects had the next genotypes; AT (25 patients, 31.3%) or TT (5 study subjects, 6.3%) (second group). In non T allele carriers, the decreases in weight−3.4±2.9kg (T allele group −1.7±2.0kg:p=0.01), BMI −1.5±0.2kg (T allele group −1.2±0.5kg:p=0.02), fat mass−2.3±1.1kg (T allele group −1.7±0.9kg:p=0.009), waist circumference−3.8±2.4cm (T allele group −2.1±3.1cm:p=0.008), triglycerides −13.2±7.5mg/dl (T allele group +2.8±1.2mg/dl:p=0.02), insulin −2.1±1.9mUI/L (T allele group −0.3±1.0mUI/L:p=0.01), HOMA-IR −0.9±0.4 (T allele group −0.1±0.8:p=0.01) and leptin −10.1±9.5ng/dl (T allele group −3.1±0.2ng/dl:p=0.01) were higher than T allele carriers. Conclusionrs10767664 variant of BDNF gene modify anthropometric and biochemical changes after weight loss with a hypocaloric diet.