Abstract
RNA-recognition motif (RRM) is an RNA-interacting protein domain that plays an important role in the processes of RNA metabolism such as the splicing, editing, export, degradation, and regulation of translation. Here, we present the RNA-recognition motif database (RRMdb), which affords rapid identification and annotation of RRM domains in a given protein sequence. The RRMdb database is compiled from ~57 000 collected representative RRM domain sequences, classified into 415 families. Whenever possible, the families are associated with the available literature and structural data. Moreover, the RRM families are organized into a network of sequence similarities that allows for the assessment of the evolutionary relationships between them.
Highlights
The RNA-recognition motif (RRM) domains are important players in the regulation of development [1], signaling [2], gene expression [3] and cell differentiation [4]
A typical RRM domain consists of approximately 90 amino acid residues that fold into a four-stranded β-sheet with two αhelices packed against it (β1–α1–β2–β3–α2–β4)
The RNA recognition by RRMs is sequence-specific and occurs via two conserved motifs RNP1 and RNP2 localized in β3 and β1, respectively [5]
Summary
Martyna Nowacka1,†, Pietro Boccaletto1,†, Elzbieta Jankowska, Tomasz Jarzynka, Janusz M. Citation details: Nowacka,M., Boccaletto,P., Jankowska,E. et al RRMdb—an evolutionary-oriented database of RNA recognition motif sequences. Database (2019) Vol 2019: article ID bay148; doi:10.1093/database/bay148
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