Abstract
Quantitative structure-retention relationships (QSRR) and quantitative structure-activity relationships (QSAR) have been used to study the chromatographic behavior and antibacterial activity of different substituted benzimidazole derivatives active against Erwinia carotovora subsp. carotovora . Linear correlations were found between retention constants, R M 0 , and partition coefficients, log P , calculated by use of different software products (log P Hyper , CS log P , mi log P , A log P , IA log P , C log P , log P Kow , and X log P ). A high-quality three-variable QSRR model was derived between R M 0 and lipophilicity log P Kow , hydration energy, and molar volume. A QSAR model was obtained between antibacterial activity and hydration energy, molar refractivity, and CS log P . The developed QSRR and QSAR models were cross-validated by the high Q 2 values obtained by the leave-one-out method.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
