RP TLC Determination of the Lipophilicity of New 10‐Substituted 2,7‐Diazaphenothiazines*

Abstract

Experimental (R M0 and log P TLC) and calculated (log P calcd) lipophilicity parameters of eleven new bioactive 10‐substituted 2,7‐diazaphenothiazines 2–12 were determined by reversed‐phase thin‐layer chromatography on RP‐18 silica plates, with acetone‐aqueous TRIS (tris(hydroxymethyl)aminomethane) buffer as the mobile phase, and obtained by the calculation program miLogP. The parameter R M0 was converted into parameter log P TLC by use of a calibration curve obtained for five standards. The lipophilicity parameters were intercorrelated and discussed in the terms of structure-lipophilicity relationships. The parameter R M0 and specific hydrophobic surface area b were significantly intercorrelated showing three congeneric subclasses of 2,7‐diazaphenothiazines 2–12. The 2,7‐diazaphenothiazine system turned out to be less lipophilic than the classical phenothiazine one. *Part CIII in the series of Azinyl Sulfides.