Abstract
The lipophilicity of fifteen anticancer-active propargyl thioquinolines has been determined by reversed-phase thin-layer chromatography with mixtures of acetone and Tris buffer, pH 7.4, as mobile phases. The R M values of the compounds decreased linearly with increasing concentration of acetone in the mobile phases. The partition coefficients (log P ) of the propargyl thioquinolines were calculated by use of the ScilogP program. Comparison of R M0 and log P ScilogP values enabled calculation of c log P values. It was found that the c log P values of the compounds correlated with their in vitro anticancer activity, expressed as ID 50 [μg mL −1 ], against a breast cancer cell line (T47D).
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