Abstract
Krishna R Gupta*, Anita R Pounikar and Milind J Umekar Author Affiliations Department of Pharmaceutical Chemistry, Smt Kishoritai Bhoyar College of Pharmacy, India Received: November 26, 2021 | Published: December 07, 2021 Corresponding author: Krishna R Gupta, Professor Department of Pharmaceutical Chemistry, Smt Kishoritai Bhoyar College of Pharmacy, Kamptee, Nagpur (MS), India DOI: 10.26717/BJSTR.2021.40.006447
Highlights
Naftidrofuryl, chemically it is a (RS)-2-(diethylamino) ethyl-3(1-naphthyl)- 2-(tetrahydro furan-2-ylmethyl) propanoate and it is available in the form of oxalic acid
A simple, rapid, precise, sensitive, economical, robust and QbD based RP -high-performance liquid chromatography (HPLC) method has been developed for Naftidrofuryl oxalate and validated as per International Conference on Harmonization (ICH) guidelines
The literature survey reveals that few analytical methods have been reported for the determination of Naftidrofuryl oxalate in biological fluids and/or pharmaceutical preparations by using high-performance liquid chromatography [7], high- performance liquid chromatography with fluorescence detection [8,9], RP-HPLC fluorimetry [10], phosphorimetry [11], phosphorescence [12,13], Phosphorimetric determination [14], ion-selective membrane electrodes method [15], spectrophotometric analysis [16], Spectrophotometric, spectrofluorimetric and voltammetric analysis [17] and Stability Indicating Methods [18] were reported till date
Summary
Naftidrofuryl, chemically it is a (RS)-2-(diethylamino) ethyl-3(1-naphthyl)- 2-(tetrahydro furan-2-ylmethyl) propanoate and it is available in the form of oxalic acid. Naftidrofuryl oxalate shows smooth muscle relaxation, increases cerebral blood flow as well as peripheral blood flow, cerebral adenosine triphosphate concentrations and glucose utilization properties attracts its pharmacological applications in the treatment of senile brain diseases a vasodilator. It is widely used in the treatment of peripheral and cerebral vascular disorders [3,4]. NFA is the metabolite of naftidrofuryl oxalate has been found in human plasma [4,19]
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