Rozlana melanoza skórna

Abstract

Malignant melanoma (MM) most commonly arises within the skin. Presence of metastasis, localized or distant, at the time of making a diagnosis is crucial, because it dictates modes of treatment, determines prognosis and the survival of patients. Diffuse melanosis cutis (DMC) is a rare disorder associated with metastatic melanoma and is a poor prognostic factor. It is characterized by diffuse blue-gray pigmentation of the skin and sclera, however, other pigmentation changes may be present (e.g. pigmentation of mucosa or nails, dark urine, etc.). The etiopathogenesis of DCM is not fully understood, however, the role of micrometastases, melanin precursors released during the lysis of MM metastases and melanocyte growth factors is considered in its development.