Abstract
temperature difference could be perceived either directly by elevated blood temperature affecting cells in the hypothalamic preoptic area, or indirectly by blood temperature first affecting peripheral neuronal receptors, which in turn stimulate the preoptic area. It would have been tempting to assume that direct heating of the blood could bypass peripheral neuronal receptors. However, because sequential skin temperatures were not recorded along with oral temperatures, this assumption cannot be established. Nevertheless, this case is a unique example of the temperature difference needed to be perceived by the central temperature regulation system in order to provoke the common efferent reflex leading to hives in CU.
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