Abstract
Background: Royal jelly (RJ) is a milky white highly viscous secretion from the salivary gland of the worker hive bees. RJ is a nutritive secretion that acts as biocatalyst in cell regeneration processes within the human body and exhibits antimicrobial effects. Materials and Methods: RJ antimicrobial activity against periodontopathic (American type cell culture) bacteria was investigated “in vitro.” Bacterial strains tested were Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), Prevotella intermedia (Pi), and Fusobacterium nucleatum (Fn). Minimum inhibitory concentration for the strains tested was determined using the method of broth dilution with the RJ sample in serial concentrations. Results: The minimum bactericidal concentration values were identical and showed bactericidal effect in the range between 12.5 and 100 μg/ml, suggesting that periodontal pathogens tested were susceptible to RJ. Conclusion: Results showed that the inhibitory effects on Pg and Pi at different concentrations demonstrated concurrent similarity, whereas higher concentrations were necessary to inhibit the growth of Aa and Fn. However, the requirement for a standardized method for quality evaluation of RJ, i.e., qualitative, quantitative, and biological activity is a necessity, and its dosage and safety must be tested before its possible in vivo application.
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